Does preoperative analysis of intrahepatic venous anastomoses improve the surgeon's intraoperative decision making? Pilot data from a case report
© Fischer et al; licensee BioMed Central Ltd. 2008
Received: 26 April 2008
Accepted: 21 August 2008
Published: 21 August 2008
Three-dimensional (3D) visualization is thought to improve the anatomical understanding of clinicians, thus improving patient safety.
A 58-year-old male was admitted to our hospital in April 2007 with a suspected metastasis of a sigmoid cancer in the Couinaud segment (CS) 7. The anatomical situation of this patient was analyzed using both a CT scan and 3D images. The initial CT scan revealed that the proximal part of the middle hepatic vein was completely missing and the metastasis in the CS 7 was closely attached to the right hepatic vein. After analyzing additional 3D images, it became clear that due to the close proximity of metastasis and right hepatic vein, the resection of the right hepatic vein was inevitable. Based on this 3D analysis, it was decided to perform a right-sided hemihepatectomy. In this case report, 3D visualization resulted in a faster and clearer understanding of the unique anatomical situation in a patient with complicated liver anatomy than transversal CT images.
The here presented data shows for the first time 3D visualization of intravenous anastomoses in the human liver. The information offered by 3D visualization is not redundant but rather serves as a true source of additional information, indicating the potential benefit of 3D visualization in surgical operation planning.
Three-dimensional (3D) visualization is thought to ameliorate anatomical understanding among surgeons as well as medical students [1–3] Better perception of anatomy improves the surgeon's ability to accurately plan and perform surgical procedures [1, 4], an effect which can result in lower morbidity and mortality rates after surgical interventions.
Our group has been working on 3D operation planning in liver surgery for many years [5–8]. Three-dimensional visualization based on CT scans is an efficient and fast tool for analyzing liver anatomy, possible resection proposals and volumetric consequences of the planned resections [5, 9, 10]. Particularly, the assessment of post-resectional functioning liver parenchyma is an important issue in planning of liver resections. Is has been shown that computer-assisted operation planning has a potential use of for assessment of functional respectability .
The existence of intrahepatic venous anastomoses (IVA) between the main stems of the hepatic veins (i.e. middle, right, and left) has been known for many years [12, 13]. Couinaud  found anastomoses between intrahepatic veins in 25 out of 30 casts and such anastomoses must be considered a reality from the anatomical point of view . The question whether these IVA exist only in pathological livers or also reflect physiological vascular patterns has been discussed heatedly from the beginning [13, 14]. However, there are a few case reports describing the importance of such anastomoses under clinical conditions [15–18].
To our knowledge, this is the first published report of 3D visualization of intravenous anastomoses in the human liver. Because 3D imaging leads to a faster and easier understanding of the individual anatomical situation, it may be an appropriate tool to potentially increase patient safety not only in visceral surgery but also in other surgical areas [19–22].
Description of the patient
The according CT scan was made available by the Radiology Department of the German Cancer Research Center, Heidelberg. The image data was acquired preoperatively during the routinely performed CT scan.
Image data were acquired with a Toshiba Aquilion 16 slice multidetector CT scanner (Toshiba, Japan). A standard bi- or triphasic liver scan with an optimized portal venous phase was performed. SureStart bolus tracking technique (130 ml Imeron 300, Altana, Germany, flow rate 4–5 ml/s) was used in all protocols to optimize vascular contrast .
Data transfer and digital postprocessing
Imaging data sets were transferred to the Department of Medical and Biological Informatics of the German Cancer Research Center using the CHILI  teleradiology system (CHILI GmbH, Heidelberg, Germany). Segmentation of the liver was performed using interactive region growing techniques as previously described by our group . The vessels were segmented using a grey-value-based volume-growing technique. The segmentation was then transformed automatically into a symbolic representation of the vascular anatomy containing the vessel paths, and locations of bifurcations as well as the vessels diameters . The origin of the left, middle, and right hepatic veins were identified, clicked upon and all depending vessels were marked automatically as branches of that particular vein. Portal veins and arteries were defined in the same manner. All results were validated by a team consisting of surgeons, radiologists and medical computing specialists.
Since the whole process from CT data to 3D viszualization preserves all positional information, 3D visualization and original CT data can be presented in a consistent manner. Several tools are available for the interactive exploration of the individual patient anatomy. One of these tools, the "re-localization tool", allowed us to define any volume element (voxel) in the CT scan and find this particular voxel within the 3D visualization. This is of special importance because the localization of intrahepatic venous shunts is more easily achieved with the help of 3D images.
Even though 3D visualization is now available for a couple of organ systems, the technique must still be described as rather new [25–27]. It has been shown in the field of liver surgery that 3D visualization leads to a better understanding of the liver anatomy and in turn improves surgical operation planning [1, 2]. In order to optimize the conception of the anatomical situation and thereby potentially improve patient safety, we routinely perform 3D analyses in preparation for liver surgery in patients with complicated liver anatomy and/or demanding surgical procedures including living-related liver transplantation .
Even though the CT images were sufficient to detect IVA, the 3D visualization improved the ability to detect IVA (Figures 3A and 3B), especially by using the features of the relocalization tool (description in Materials and Method section) which enables parallel searching for IVA in the CT scan and the 3D visualization. This parallel approach enabled us to detect intrahepatic anastomoses which could have been missed if only two-dimensional CT scans had been examined (figures 3A and 3B). Further, within the freely movable 3D images, the IVA could be detected very easily and fast. In contrast, the determination of IVA is time consuming with two-dimensional CT scans because one has to go back and forth within the image slices to follow the course of the IVA in order to find their drainage vessels.
The here presented data suggests that the information offered by 3D visualization is not redundant but rather serves as a true source of additional information especially in patients with complicated liver anatomy.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
- Lamade W, Glombitza G, Fischer L, Chiu P, Cardenas CE, Thorn M, Meinzer HP, Grenacher L, Bauer H, Lehnert T, Herfarth C: The impact of 3-dimensional reconstructions on operation planning in liver surgery. Arch Surg. 2000, 135: 1256-1261. 10.1001/archsurg.135.11.1256.View ArticlePubMedGoogle Scholar
- Herfarth C, Lamade W, Fischer L, Chiu P, Cardenas C, Thorn M, Vetter M, Grenacher L, Meinzer HP: The effect of virtual reality and training on liver operation planning. Swiss Surg. 2002, 8: 67-73. 10.1024/1023-9318.104.22.168.View ArticlePubMedGoogle Scholar
- Mastrangelo MJ, Adrales G, McKinlay R, George I, Witzke W, Plymale M, Witzke D, Donnelly M, Stich J, Nichols M, Park AE: Inclusion of 3-D computed tomography rendering and immersive VR in a third year medical student surgery curriculum. Stud Health Technol Inform. 2003, 94: 199-203.PubMedGoogle Scholar
- Wente MN, Thorn M, Radeleff B, Dei-Anane G, Mehrabi A, Sauer P, Buchler MW, Schmidt J, Kraus TW, Schemmer P: A routine liver transplantation in a patient with situs inversus: a case report and an overview of the literature. Clin Transplant. 2006, 20: 151-155. 10.1111/j.1399-0012.2005.00456.x.View ArticlePubMedGoogle Scholar
- Neumann JO, Thorn M, Fischer L, Schobinger M, Heimann T, Radeleff B, Schmidt J, Meinzer HP, Buchler MW, Schemmer P: Branching patterns and drainage territories of the middle hepatic vein in computer-simulated right living-donor hepatectomies. Am J Transplant. 2006, 6: 1407-1415. 10.1111/j.1600-6143.2006.01315.x.View ArticlePubMedGoogle Scholar
- Fischer L, Thorn M, Neumann JO, Schobinger M, Heimann T, Grenacher L, Meinzer HP, Friess H, Buchler MW: The segments of the hepatic veins-is there a spatial correlation to the Couinaud liver segments?. Eur J Radiol. 2005, 53: 245-255. 10.1016/j.ejrad.2004.02.003.View ArticlePubMedGoogle Scholar
- Glombitza G, Evers H, Hassfeld S, Engelmann U, Meinzer HP: Virtual surgery in a (tele-)radiology framework. IEEE Trans Inf Technol Biomed. 1999, 3: 186-196. 10.1109/4233.788580.View ArticlePubMedGoogle Scholar
- Fischer L, Cardenas C, Thorn M, Benner A, Grenacher L, Vetter M, Lehnert T, Klar E, Meinzer HP, Lamade W: Limits of Couinaud's liver segment classification: a quantitative computer-based three-dimensional analysis. J Comput Assist Tomogr. 2002, 26: 962-967. 10.1097/00004728-200211000-00019.View ArticlePubMedGoogle Scholar
- Oldhafer KJ, Preim B, Dorge C, Peitgen HO, Broelsch CE: [Acceptance of computer-assisted surgery planning in visceral (abdominal) surgery]. Zentralbl Chir. 2002, 127: 128-133. 10.1055/s-2002-22029.View ArticlePubMedGoogle Scholar
- Ritter F, Hansen C, Dicken V, Konrad O, Preim B, Peitgen HO: Real-time illustration of vascular structures. IEEE Trans Vis Comput Graph. 2006, 12: 877-884. 10.1109/TVCG.2006.172.View ArticlePubMedGoogle Scholar
- Lang H, Radtke A, Liu C, Sotiropoulos GC, Hindennach M, Schroeder T, Peitgen HO, Broelsch CE: Improved assessment of functional resectability in repeated hepatectomy by computer-assisted operation planning. Hepatogastroenterology. 2005, 52: 1645-1648.PubMedGoogle Scholar
- Couinaud C, Noguiera C: Les Veines Sus-Hépatiques Chez l'Homme . Acta Anat. 1958, 34: 84-110. 10.1159/000141374.View ArticlePubMedGoogle Scholar
- Masselot R, Leborgne J: Anatomical study of the hepatic veins. Anat Clin. 1978, 1: 109-125. 10.1007/BF01654491.View ArticleGoogle Scholar
- Guntz M: Anatomie et radio-anatomie. Trav lab Anat Fac Med. 1959Google Scholar
- Cescon M, Sugawara Y, Sano K, Ohkubo T, Kaneko J, Makuuchi M: Right liver graft without middle hepatic vein reconstruction from a living donor. Transplantation. 2002, 73: 1164-1166. 10.1097/00007890-200204150-00028.View ArticlePubMedGoogle Scholar
- Kaneko T, Kaneko K, Sugimoto H, Inoue S, Hatsuno T, Sawada K, Ando H, Nakao A: Intrahepatic anastomosis formation between the hepatic veins in the graft liver of the living related liver transplantation: observation by Doppler ultrasonography. Transplantation. 2000, 70: 982-985. 10.1097/00007890-200009270-00018.View ArticlePubMedGoogle Scholar
- Sugimoto H, Kaneko T, Nakao A: Anastomosis between the middle and right hepatic vein. Hepatogastroenterology. 2002, 49: 1257-1258.PubMedGoogle Scholar
- Sano K, Makuuchi M, Takayama T, Sugawara Y, Imamura H, Kawarasaki H: Technical dilemma in living-donor or split-liver transplant. Hepatogastroenterology. 2000, 47: 1208-1209.PubMedGoogle Scholar
- Fried MP, Uribe JI, Sadoughi B: The role of virtual reality in surgical training in otorhinolaryngology. Curr Opin Otolaryngol Head Neck Surg. 2007, 15: 163-169.View ArticlePubMedGoogle Scholar
- Endo I, Shimada H, Takeda K, Fujii Y, Yoshida K, Morioka D, Sadatoshi S, Togo S, Bourquain H, Peitgen HO: Successful duct-to-duct biliary reconstruction after right hemihepatectomy. Operative planning using virtual 3D reconstructed images. J Gastrointest Surg. 2007, 11: 666-670. 10.1007/s11605-007-0130-2.View ArticlePubMedGoogle Scholar
- Suzuki S, Eto K, Hattori A, Yanaga K, Suzuki N: Surgery simulation using patient-specific models for laparoscopic colectomy. Stud Health Technol Inform. 2007, 125: 464-466.PubMedGoogle Scholar
- Clarke JR, Marella W, Johnston J, Davis M: A surgeon who CARES can be safer. Am J Surg. 2005, 190: 356-358. 10.1016/j.amjsurg.2005.05.039.View ArticlePubMedGoogle Scholar
- Engelmann U, Schwab M, Schroter A, Rusu P, Meinzer HP: [Evaluation of CHILI teleradiology network 4 years after clinical implementation]. Radiologe. 2002, 42: 87-93. 10.1007/s00117-001-0696-8.View ArticlePubMedGoogle Scholar
- Meinzer HP, Thorn M, Cardenas C: Computerized planning of liver surgery - an overview. Computers & Graphics. 2002, 26: 569-576. 10.1016/S0097-8493(02)00102-4.View ArticleGoogle Scholar
- Hallscheidt PJ, Thorn M, Radeleff BA, Noeldge G, Shab A, Meinzer P, Boese JM: Comparison of spatial resolution in high-resolution multislice computed tomography and digital subtraction angiography using renal specimens. J Comput Assist Tomogr. 2003, 27: 864-868. 10.1097/00004728-200311000-00005.View ArticlePubMedGoogle Scholar
- Grenacher L, Thorn M, Knaebel HP, Vetter M, Hassenpflug P, Kraus T, Meinzer HP, Buchler MW, Kauffmann GW, Richter GM: [The role of 3-D imaging and computer-based postprocessing for surgery of the liver and pancreas]. Rofo. 2005, 177: 1219-1226.View ArticlePubMedGoogle Scholar
- De SR, Glombitza G, Vahl CF, Meinzer HP, Hagl S: Three-dimensional color Doppler flow reconstruction and its clinical applications. Echocardiography. 2000, 17: 765-771. 10.1111/j.1540-8175.2000.tb01235.x.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.