The influence of iron status and genetic polymorphisms in the HFE gene on the risk for postoperative complications after bariatric surgery: a prospective cohort study in 1,064 patients

Table 7 Summary of 30-day wound complications in patients undergoing OPEN RYGB

Wound Complications	None N = 556	Any N = 84	Any vs. None p-value
Hepatic Iron Staining	109 (20%)	14 (17%)	0.66²
Serum iron (ug/dL)*
Median [Q1, Q3]	59 [47, 75]	62 [52, 81]	0.18¹
Abnormal (% > 55)	2 (<1%)	2 (3%)	0.097²
Ferritin (ng/mL)*
Median [Q1, Q3]	103 [55, 167]	94 [62, 184]	0.89¹
Abnormal (% > 55)	21 (4%)	2 (3%)	0.76²
Iron binding capacity (ug/dL)*
Median [Q1, Q3]	314 [288, 347]	323 [284, 353]	0.73¹
Abnormal (% > 55)	13 (3%)	2 (3%)	0.99²
Transferrin saturation (%)*
Median [Q1, Q3]	19 [15, 25]	21 [16, 26]	0.33¹
Abnormal (% > 55)	0 (0%)	3 (4%)	0.0027²
C282Y
Normal/Hetero, N (%)	555 (99%)	84 (100%)	0.99¹
Homo, N (%)	1 (<1%)	0 (0%)
H63D
Normal/Hetero, N (%)	543 (98%)	79 (94%)	0.074¹
Homo, N (%)	13 (2%)	5 (6%)
C282Y/H63D**
Allele dose <2	535 (96%)	75 (89%)	0.010¹
Allele dose 2+	21 (4%)	9 (11%)

*Serum iron, ferritin, iron binding capacity, and transferring saturation were available for n = 541, n = 546, n = 542, and n = 540 subjects, respectively.
**An allele dose of 2+ includes all that were homozygous for C282Y, homozygous for H63D, and compound heterozygous for both C282Y and H63D.
¹ Chi-square ² Fisher's Exact test

ISSN: 1754-9493