Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective

Table 1 Diagnostic Concepts

Concept of developing treatment's Algorithms
Osteoporosis	-Idenitifcation of Patient's phenotype
	- Patient Screening
	-Poor nutrition and exercise is an indicator for Osteoporosis
	-Defects in collagen 1a1 and 1a2 genes
	-Variations of the Wnt coreceptor; LPR5;
Osteolysis and implant loosening	-Variations in the TNF gene promoter
	-IL-1 gene family and related protein 3
Monitoring patients postsurgically	-Urine metal ion level, serum cytokine, lymphocyte response
Mechanotransduction signaling and skeletal repair	-COX2
Acute systemic inflammation and bone resorption	-TNF-α, IL-6, translocation of NF-kappa-B and TNF-alpha-mRNA expression in peripheral blood monocytes
Posttraumatic stress	-Trauma-focused cognitive-behavioral therapy
Cell viability, Osteoblast differentiation, gene expression of osteoblasts	-Level of canonical Wnt-,IGF-, TGF-β, FGF

Concept of developing treatment's Algorithms: Modified according to Cuomo AV, Lieberman JR (modified version, adapted from Ref #[6])

ISSN: 1754-9493