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Table 1 Diagnostic Concepts

From: Challenges and barriers to improving care of the musculoskeletal patient of the future - a debate article and global perspective

Concept of developing treatment's Algorithms
Osteoporosis -Idenitifcation of Patient's phenotype
  - Patient Screening
  -Poor nutrition and exercise is an indicator for Osteoporosis
  -Defects in collagen 1a1 and 1a2 genes
  -Variations of the Wnt coreceptor; LPR5;
Osteolysis and implant loosening -Variations in the TNF gene promoter
  -IL-1 gene family and related protein 3
Monitoring patients postsurgically -Urine metal ion level, serum cytokine, lymphocyte response
Mechanotransduction signaling and skeletal repair -COX2
Acute systemic inflammation and bone resorption -TNF-α, IL-6, translocation of NF-kappa-B and TNF-alpha-mRNA expression in peripheral blood monocytes
Posttraumatic stress -Trauma-focused cognitive-behavioral therapy
Cell viability, Osteoblast differentiation, gene expression of osteoblasts -Level of canonical Wnt-,IGF-, TGF-β, FGF
  1. Concept of developing treatment's Algorithms: Modified according to Cuomo AV, Lieberman JR (modified version, adapted from Ref #[6])