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Table 2 Percentage of infection frequency of modular mega-implants in the lower extremities in the literature

From: Periprosthetic joint infections in modular endoprostheses of the lower extremities: a retrospective observational study in 101 patients

Author/ year System Number of patients Locations Follow-up time Infections Comments
Roberts et al. 1991[25] STANMORE™ 135 knee not specified 6.8 %  
Unwin et al. 1996 [26] STANMORE™ 1001 hip, knee, femur shaft 46 months 24.6 %  
Mascard et al. 1998 [27] GUEPAR™ 90 knee 4.3 years (1–22 years) 13 %  
Ilyas et al. 2001 [28] HMR- System 48 knee 5.6 years (2–10 years) 14.6 %  
Donati et al. 2001 [15] KMFTR-System 34 knee 10 years 4 %  
Mittermayer et al. 2001 [16] KMFTR-System 100 hip, knee, femur shaft 127.5 months 9.7 % 51 patients died and 41 patients analysed
Ilyas et al. 2002 [14] HMR- System 15 knee 6.7 years (3–10 years) 13.3 %  
Griffin et al. 2005 [29] several 99 hip, knee, femur shaft 6 years (3.2–158.9 months) 10.1 %  
Heisel et al. 2006 [17] MUTARS 50 hip, knee, femur shaft 46 monts (2–7 years) 12 %  
Gosheger et al. 2006 [13] MUTARS 250 hip, knee, femur shaft not specified 12 %  
Gerdesmeyer et al. 2006 [30] MML-System 70 hip, knee, femur shaft 7 years +/− 28 months none drop-out 46 %
Gradinger and Gollwitzer 2006 [12] MML-System 89 hip, knee, femur shaft not specified 3.3 %  
Hardes et al. 2009 [31] MUTARS 28 hip, knee not specified 7.1 % without tumor
Chandrasekar 2009 [32] STANMORE™ 100 hip 24.6 months (0–60 months) 4 %  
Kinkel et al. 2010 [33] MUTARS 77 hip, knee, femur shaft not specified 11.7 % 60 % complications
von Salis-Soglio et al. 2010 [10] MML-System 572 hip, knee, femur shaft not specified 10.5 %  
Ruggeri et al. 2010 [34] KMFTR, HMRS, GMRS 28 complete femur 8 months (1 month −17 years) 7.1 %  
Winkelmann et al. 2010 [35] MUTARS 41 hip, knee, femur shaft 45 months 19.5 %  
Pala et al. 2015 [36] GMRS 247 knee 4 years (2–8 years) 9.3 %  
Capanna et al. 2015 [37] several 278 hip, knee more than 2 years 8.3 %  
Sevelda et al. 2015 [38] several 50 complete femur 57 months (1–280 months) 12 %