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Table 1 Demographic and clinicopathologic data of all patients

From: Breast cancer involvement of the nipple-areola complex and implications for nipple-sparing mastectomies: a retrospective observational study in 137 patients

  All patients Patients with NAC
N = 12
Patients without NAC
N = 125
p-value
Age 47.39 ± 8.01 50.9 ± 6.8 47.1 ± 8.1 0.136 a
32–58   
Age subgroups 30–39 35 (25.5) 2 (16.7) 33 (26.4) 0.686 b
40–49 37 (27) 3 (25) 34 (27.2)
≥ 50 65 (47.4) 7 (58.3) 58 (46.4)
Tumor size 2.9 ± 1.16 4.18 ± 1.16 2.35 ± 1.1 <0.001 a
Range 1–6   
<  4 cm 101 (73.7) 4 (33.3) 97 (77.6) 0.003 b
≥ 4 cm 36 (26.3) 8 (66.7) 28 (22.4)
Tumor nipple distance 3.38 ± 0.92 1.95 ± 0.72 3.52 ± 0.84 <0.001a
Range 1.4–6   
<  2 cm 6 (4.4) 4 (33.3) 2 (1.6) <0.001 ɑ
2 – < 2.5 cm 11 (8) 2 (16.7) 9 (7.2)
2.5 - <  3 cm 4 (2.9) 3 (25) 1 (0.8)
3 - <  4 cm 79 (57.7) 1 (8.3) 78 (62.4)
≥ 4 cm 37 (27) 2 (16.7) 35 (28)
Tumor site Upper inner 22 (16.1) 1 (8.3) 21 (16.8) 0.470 b
Upper outer 26 (19.1) 2 (16.7) 24 (19.2)
Lower inner 31 (22.6) 1 (8.3) 30 (24)
Lower outer 7 (5.1) 1 (8.3) 6 (4.8)
Central 51 (37.2) 7 (58.3) 44 (35.2)
Histologic type DCIS 32 (23.4) 5 (41.7) 27 (21.6) 0.033 b
IDC 37 (27) 5 (41.7) 32 (25.6)
LCIS 43 (31.4) 1 (8.3) 42 (33.6)
ILC 25 (18.2) 1 (8.3) 24 (19.2)
histologic grade Grade I 63 (46) 2 (16.7) 61 (48.8) 0.003 b
Grade II 39 (28.5) 2 (16.7) 37 (29.6)
Grade III 35 (25.5) 8 (66.7) 27 (21.6)
Lymph node involvement Positive 39 (28.5) 9 (75) 30 (24) 0.001b
Lymph node numbers <  4 13 (9.5) 0 (8.3) 13 (43.3) <0.001 ɑ
4 - < 10 14 (10.2) 1 (11.1) 13 (43.3)
≥ 10 12 (8.8) 8 (88.9) 4 (13.3)
Staging II 80 (58.4) 3 (27.3) 77 (61.6) 0.032 b
III 57 (41.6) 8 (72.7) 49 (38.9)
Multifocal tumor 13 (9.5) 4 (33.3) 9 (7.2) 0.016 b
Multicenteric 14 (10.2) 5 (41.7) 9 (7.2) 0.003 b
Lymphovascular invasion 21 (15.3) 5 (41.7) 16 (12.8) 0.020 b
Estrogen receptor status 13 (9.5) 6 (50) 7 (5.6) <0.001b
Progesterone receptor status 12 (8.8) 7 (58.3) 5 (4) <0.001b
HER status 17 (12.4) 7 (58.3) 10 (8) <0.001b
  1. a:Mann Whitney test b: Fischer exact test ɑ: Wilcoxon sign test