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Table 2 Predictors of NAC involvement

From: Breast cancer involvement of the nipple-areola complex and implications for nipple-sparing mastectomies: a retrospective observational study in 137 patients

   RR CI (95%) Wald p-value
Lower upper
Age subgroups < 40 versus > 40 years 1.99 0.391 10.14 0.687 0.407
> 40 versus > 50 years 1.36 0.332 5.64 0.188 0.665
Tumor size
<  4 versus ≥ 4 cm
6.92 1.94 24.17 8.89 0.003
Tumor nipple distance
<  3 cm
< 2 versus > 2 cm 0.029 0.003 0.262 9.88 0.002
< 2.5 versus > 2.5 cm 0.019 0.001 0.276 8.42 0.004
<  3 versus > 3 cm 0.257 0.032 2.08 1.61 0.203
<  4 versus > 4 cm 4.45 0.391 50.79 1.44 0.229
Lymph node metastasis Metastasis versus no metastasis 9.5 2.41 37.37 10.37 <0.001
≥ 10versus < 10 26.00 2.45 275.82 7.31 0.007
Multifocal tumor Multifocal versus not multifocal 6.44 1.62 25.58 7.01 0.008
Multicenteric Multicentric versus not multicentric 9.20 2.42 34.91 10.65 <0.001
Lymphovascular invasion Invasion versus noninvasion 4.86 1.37 17.18 6.04 0.014
Estrogen receptor status ER - versus ER+ 16.85 4.30 65.97 16.46 <0.001
Progesterone receptor status PR - versus PR+ 33.60 7.84 143.97 22.40 <0.001
HER status HER + versus HER - 16.0 4.31 60.09 17.10 <0.001
Staging III Stage III versus II 4.19 1.1 16.56 4.17 0.041
Histologic tumor type DCIS versus ILC 0.225 0.025 2.06 1.74 0.187
DCIS versus IDC 0.267 0.029 2.43 1.37 0.241
IDC versus ILC 1.75 0.105 29.26 0.152 0.697
Histologic grade Grade III versus grade I 9.03 1.79 45.40 7.14 0.008
Grade III versus grade II 5.48 1.07 27.89 4.20 0.040