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Table 2 Patient demographics and surgical characteristics in total population and broken down by pain failure (pain score > 5) in first 48 h post-op

From: Risk factors for liposomal bupivacaine resistance after total hip or knee arthroplasties: a retrospective observational cohort in 237 patients

 

Total (n = 237)

Pain Failure in 0–6 h

Pain Failure in 6-12 h

Pain Failure in 12-24 h

Pain Failure in 24-48 h

No

Yes

p-value

No

Yes

p-value

No

Yes

p-value

No

Yes

p-value

Gender

   

0.37

  

0.30

  

0.86

  

0.71

 Male

71 (31.4)

47 (33.6)

24 (27.9)

 

33 (29.0)

23 (36.5)

 

19 (33.9)

46 (32.6)

 

12 (28.6)

52 (31.5)

 

 Female

155 (68.6)

93 (66.4)

62 (72.1)

 

81 (71.1)

40 (63.5)

 

37 (66.1)

95 (67.4)

 

30 (71.4)

113 (68.5)

 

Age

62.8 ± 10.8

64.6 ± 10.0

60.0 ± 11.5

0.002

63.8 ± 10.4

58.8 ± 11.8

0.004

64.7 ± 10.0

61.7 ± 10.9

0.08

66.5 ± 10.3

61.8 ± 10.7

0.01

BMI

32.4 ± 11.8

31.7 ± 6.2

33.6 ± 17.4

0.24

31.4 ± 6.6

34.2 ± 20.1

0.17

30.2 ± 6.0

33.7 ± 13.9

0.07

30.5 ± 6.5

32.8 ± 18.1

0.30

Side

   

0.45

  

0.34

  

0.25

  

0.70

 Right

133 (58.3)

85 (60.3)

48 (55.2)

 

70 (61.4)

34 (54.0)

 

36 (64.3)

79 (55.2)

 

23 (54.8)

97 (58.1)

 

 Left

95 (41.7)

56 (39.7)

39 (44.8)

 

44 (38.6)

29 (46.0)

 

20 (35.7)

64 (44.8)

 

19 (45.2)

70 (41.9)

 

Surgery

   

0.03

  

0.16*

  

0.14*

  

0.36*

 Primary Total Knee

122 (54.7)

72 (52.6)

50 (58.1)

 

64 (57.7)

37 (58.7)

 

26 (47.3)

85 (60.7)

 

22 (56.4)

92 (55.4)

 

 Revision Total Knee

18 (8.1)

10 (7.3)

8 (9.3)

 

7 (6.3)

3 (4.8)

 

3 (5.5)

12 (8.6)

 

3 (7.7)

13 (7.8)

 

 Primary Total Hip

66 (29.6)

48 (35.0)

18 (20.9)

 

37 (33.3)

17 (27.0)

 

22 (40.0)

31 (22.1)

 

14 (35.9)

46 (27.7)

 

 Revision Total Hip

15 (6.7)

5 (3.7)

10 (11.6)

 

2 (1.8)

6 (9.5)

 

4 (7.3)

10 (7.1)

 

0

13 (7.8)

 

 Bilateral Knee

2 (0.9)

2 (1.5)

0

 

1 (0.9)

0

 

0

2 (1.4)

 

0

2 (1.2)

 

PCA

   

0.36

  

0.86

  

0.03

  

0.15

 Yes

49 (21.3)

109 (76.8)

72 (81.8)

 

90 (78.3)

50 (79.4)

 

38 (69.1)

120 (83.3)

 

31 (72.1)

137 (82.0)

 

 No

181 (78.7)

33 (23.2)

16 (18.2)

 

25 (21.7)

13 (20.6)

 

17 (30.9)

24 (16.7)

 

12 (27.9)

30 (18.0)

 

Type of Block

   

0.42

  

0.76

  

0.37

  

0.68

 None

193 (83.9)

117 (82.4)

76 (86.4)

 

96 (83.5)

55 (87.3)

 

42 (76.4)

122 (84.7)

 

37 (86.1)

137 (82.0)

 

 Spinal/Epidural

26 (11.3)

19 (13.4)

7 (8.0)

 

13 (11.3)

5 (7.9)

 

10 (18.2)

16 (11.1)

 

5 (11.6)

21 (12.6)

 

 Femoral/Intraarticular

11 (4.8)

6 (4.2)

5 (5.7)

 

6 (5.2)

3 (4.8)

 

3 (5.5)

6 (4.2)

 

1 (2.3)

9 (5.4)

 

Smoker

   

0.04

  

0.20

  

0.29

  

0.05

 Yes

47 (21.0)

23 (16.6)

24 (28.2)

 

20 (17.7)

16 (25.8)

 

9 (16.1)

32 (22.9)

 

4 (9.5)

38 (23.3)

 

 No

177 (79.0)

116 (83.5)

61 (71.8)

 

93 (82.3)

46 (74.2)

 

47 (83.9)

108 (77.1)

 

38 (90.5)

125 (76.7)

 

Alcohol

   

0.49

  

0.23

  

0.54

  

0.11

 Yes

42 (18.7)

24 (17.3)

18 (20.9)

 

17 (15.0)

14 (22.2)

 

9 (16.1)

28 (19.9)

 

4 (9.5)

33 (20.1)

 

 No

183 (81.3)

115 (82.7)

68 (79.1)

 

96 (85.0)

49 (77.8)

 

47 (83.9)

113 (80.1)

 

38 (90.5)

131 (79.9)

 

Hx Pain Management

   

0.09

  

0.0003

  

0.25

  

0.01

 Yes

94 (41.8)

52 (37.4)

42 (48.8)

 

38 (33.3)

38 (61.3)

 

20 (36.4)

64 (45.4)

 

11 (26.2)

79 (48.2)

 

 No

131 (58.2)

87 (62.6)

44 (51.2)

 

76 (66.7)

24 (38.7)

 

35 (63.6)

77 (54.6)

 

31 (73.8)

85 (51.8)

 

Home Pain Meds

   

0.11

  

0.001*

  

0.20*

  

0.004*

 None

130 (57.5)

86 (61.4)

44 (51.2)

 

76 (66.7)

24 (38.1)

 

34 (60.7)

77 (54.6)

 

31 (73.8)

84 (50.9)

 

 Opioids

70 (31.0)

36 (25.7)

34 (39.5)

 

27 (23.7)

32 (50.8)

 

13 (23.2)

50 (35.5)

 

5 (11.9)

63 (38.2)

 

 Neurontin/Lyrica

9 (4.0)

5 (3.6)

4 (4.7)

 

5 (4.4)

2 (3.2)

 

2 (3.6)

6 (4.3)

 

1 (2.4)

7 (4.2)

 

 Other

17 (7.5)

13 (9.3)

4 (4.7)

 

6 (5.3)

5 (7.9)

 

7 (12.5)

8 (5.7)

 

5 (11.9)

11 (6.7)

 

Steroids

   

0.63

  

0.87

  

0.54

  

0.77*

 Yes

21 (9.3)

12 (8.6)

9 (10.5)

 

10 (8.8)

6 (9.5)

 

4 (7.1)

14 (9.9)

 

3 (7.1)

17 (10.3)

 

 No

205 (90.7)

128 (91.4)

77 (89.5)

 

104 (91.2)

57 (90.5)

 

52 (92.9)

127 (90.1)

 

39 (92.9)

148 (89.7)

 

Antidepressants

   

0.14

  

0.18

  

0.53

  

0.79*

 Yes

23 (10.1)

11 (7.9)

12 (14.0)

 

9 (7.9)

9 (14.3)

 

5 (8.9)

17 (12.1)

 

5 (11.9)

18 (10.9)

 

 No

203 (89.8)

129 (92.1)

74 (86.1)

 

105 (92.1)

54 (85.7)

 

51 (91.1)

124 (87.9)

 

37 (88.1)

147 (89.1)

 

Diabetes

   

0.45

  

0.12

  

0.94

  

0.93

 Yes

67 (29.7)

44 (31.4)

23 (26.7)

 

40 (35.1)

15 (23.8)

 

16 (28.6)

41 (29.1)

 

13 (31.0)

50 (30.3)

 

 No

159 (70.4)

96 (68.6)

63 (73.3)

 

74 (64.9)

48 (76.2)

 

40 (71.4)

100 (70.9)

 

29 (69.1)

115 (69.7)

 
  1. *Fisher-Exact tests were used in place of chi-square tests to obtain p-values were > 25% of cells have expected counts < 5
  2. Bold indicates clinical significance < 0.05