Table 3 Univariate and independent associations with pharmacologic prophylaxis administration in the intensive care unit
Pharmacologic prophylaxis administered | Substantially delayed pharmacologic initiationa | |||
|---|---|---|---|---|
Unadjusted OR (95% CI) | Adjusted OR (95% CI) | Unadjusted OR (95% CI) | Adjusted OR (95% CI) | |
ICU admitting service | ||||
Non-trauma service | Ref | Ref | Ref | Ref |
Trauma service | 1.50 (0.86–2.61) | 2.88 (1.21–6.83) | 7.96 (2.89–21.95) | 8.30 (2.18–31.56) |
Age | 0.99 (0.97–1.00) | 0.98 (0.96–1.00) | ||
Sex | ||||
Male | Ref | Ref | ||
Female | 0.80 (0.43–1.47) | 0.61 (0.24–1.58) | ||
Race | ||||
White | Ref | Ref | ||
Black | 1.46 (0.80–2.66) | 1.29 (0.55–3.04) | ||
Other/unknown | 1.75 (0.47–6.46) | 0.34 (0.04–3.14) | ||
Hospital length of stay | 1.05 (1.01–1.08) | 1.04 (1.00–1.09) | 1.15 (1.03–1.28) | |
ICU length of stay | 1.10 (1.02–1.19) | 1.13 (1.05–1.21) | 1.06 (0.99–1.13) | |
Pre-admission anticoagulants | 0.59 (0.27–1.31) | 3.00 (0.89–10.07) | ||
Comorbidities | ||||
Hypertension | 1.16 (0.66–2.05) | 0.73 (0.31–1.70) | ||
Smoking | 1.23 (0.58–2.60) | 2.13 (0.70–6.46) | ||
Diabetes | 0.92 (0.40–2.14) | 0.80 (0.22–2.88) | ||
Liver disease | 1.01 (0.31–3.25) | 0.81 (0.14–4.68) | 0.07 (0.01–0.92) | |
Obesity | 1.45 (0.44–4.72) | 0.10 (0.01–2.13) | ||
History of VTE | 0.33 (0.03–3.23) | 0.53 (0.01–50.75) | ||
Kidney disease | 0.14 (0.01–4.34) | – | ||
Cancer | 0.20 (0.01–8.24) | – | ||
Traumatic injury | 1.19 (0.68–2.07) | 7.44 (2.70–20.47) | ||
Head injury | 0.24 (0.12–0.48) | 0.22 (0.08–0.59) | 5.28 (1.52–18.36) | |