Skip to main content

Table 3 Univariate and independent associations with pharmacologic prophylaxis administration in the intensive care unit

From: Compliance with American College of Chest Physicians (ACCP) recommendations for thromboembolic prophylaxis in the intensive care unit: a level I trauma center experience

  Pharmacologic prophylaxis administered Substantially delayed pharmacologic initiationa
Unadjusted
OR (95% CI)
Adjusted
OR (95% CI)
Unadjusted
OR (95% CI)
Adjusted
OR (95% CI)
ICU admitting service
 Non-trauma service Ref Ref Ref Ref
 Trauma service 1.50 (0.86–2.61) 2.88 (1.21–6.83) 7.96 (2.89–21.95) 8.30 (2.18–31.56)
Age 0.99 (0.97–1.00)   0.98 (0.96–1.00)  
Sex
 Male Ref   Ref  
 Female 0.80 (0.43–1.47)   0.61 (0.24–1.58)  
Race
 White Ref   Ref  
 Black 1.46 (0.80–2.66)   1.29 (0.55–3.04)  
 Other/unknown 1.75 (0.47–6.46)   0.34 (0.04–3.14)  
Hospital length of stay 1.05 (1.01–1.08)   1.04 (1.00–1.09) 1.15 (1.03–1.28)
ICU length of stay 1.10 (1.02–1.19) 1.13 (1.05–1.21) 1.06 (0.99–1.13)  
Pre-admission anticoagulants 0.59 (0.27–1.31)   3.00 (0.89–10.07)  
Comorbidities
 Hypertension 1.16 (0.66–2.05)   0.73 (0.31–1.70)  
 Smoking 1.23 (0.58–2.60)   2.13 (0.70–6.46)  
 Diabetes 0.92 (0.40–2.14)   0.80 (0.22–2.88)  
 Liver disease 1.01 (0.31–3.25)   0.81 (0.14–4.68) 0.07 (0.01–0.92)
 Obesity 1.45 (0.44–4.72)   0.10 (0.01–2.13)  
 History of VTE 0.33 (0.03–3.23)   0.53 (0.01–50.75)  
 Kidney disease 0.14 (0.01–4.34)   
 Cancer 0.20 (0.01–8.24)   
Traumatic injury 1.19 (0.68–2.07)   7.44 (2.70–20.47)  
Head injury 0.24 (0.12–0.48) 0.22 (0.08–0.59) 5.28 (1.52–18.36)  
  1. Bold indicates statistically significant results at a threshold of P ≤ 0.05. aSubstantially delayed initiation of pharmacologic VTE prophylaxis was defined as initiation > 48 h after admission to the ICU. OR odds ratio, 95% CI 95% confidence interval, ICU intensive care unit, VTE venous thromboembolism