Table 1 Historical landmarks in vaccine development
18th Century | 19th Century | 20th Century (1st half) | 20th Century (2nd half) | 21st Century |
|---|---|---|---|---|
Smallpox | Rabies | Diphtheria Toxoid | Polio | Pneumococcal Conjugates |
| Â | Typhoid | Tetanus Toxoid | Measles | Meningococcal Conjugates |
| Â | Cholera | Pertussis | Mumps | HPV |
| Â | Plague | Tuberculosis | Rubella | Zoster |
| Â | Â | Yellow Fever | Anthrax | Rotavirus |
| Â | Â | Influenza | Adenovirus | Cholera |
| Â | Â | Rickettsia | Tick Encephalitis | Japanese Encephalitis |
| Â | Â | Â | Hepatitis B | Pneumococcal Conjugates SARS-CoV-2 |