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Table 4 Secondary outcomes

From: Compliance to perioperative anticoagulation protocols in elderly patients undergoing elective orthopedic procedures: a retrospective observational cohort study on 548 patients

 

VKA users

N = 319

DOAC users

N = 229

P-value

Preoperative (%)

 Administration of vitamin K

28

(9%)

-

-

 

 Administration of coagulations factors

1

(0%)

-

-

 

Non-reporting of anticoagulation management as decided by pbysician

15

(5%)

4

(2%)

0.06

Non-reporting of exact timing of interruption as executed by patient

174

(55%)

92

(40%)

 < 0.001

Conflicting information about perioperative anticoagulant management in medical records

106

(33%)

46

(20%)

 < 0.001

Perioperative (%)

 Mean blood loss during surgery (SD)

252

(227)

210

(145)

0.041

 > 500 ml unexpected blood loss during surgery

12

(4%)

2

(1%)

0.106

Postoperative untill six weeks after surgery

 Coagulation-related complications, total

37

(12%)

22

(10%)

0.10

 Tromboembolic complications

2

(1%)

6

(3%)

0.06

Bleeding complications

37

(12%)

20

(9%)

0.30

 Clinical relevant non-major bleeding

29

(9%)

18

(8%)

0.61

 Major bleeding

8

(3%)

2

(1%)

0.16

Administration of blood transfusion

24

(8%)

6

(2%)

0.013

  1. DOAC Direct oral anticoagulants, VKA Vitamin K antagonist, SD standard deviation