https://pssjournal.biomedcentral.com/articles/10.1186/1754-9493-2-17
https://pssjournal.biomedcentral.com/articles/10.1186/1754-9493-2-14
https://pssjournal.biomedcentral.com/articles/10.1186/1754-9493-2-16
https://pssjournal.biomedcentral.com/articles/10.1186/1754-9493-2-15