Misinterpretation of histopathological results as an important risk factor for unneeded surgery – case report of a "near miss" event in a pregnant woman
© Løes and Tornes; licensee BioMed Central Ltd. 2008
Received: 28 March 2008
Accepted: 05 June 2008
Published: 05 June 2008
The oral cavity may exhibit a vast number of pathologic conditions, often dealt with by different medical disciplines. Combined with a substantial variation in clinical appearance, an accurate diagnosis may provide difficult to establish in selected cases. Histopathological investigations are therefore mandatory for correct diagnosis and adequate treatment. We describe a common, truly benign condition in the oral cavity, which due to histopathological misinterpretation was planned for major surgery and subsequent chemotherapy. This was avoided by spontaneous regression of the lesion. The case illustrates that uncritical trust in laboratory diagnostic tests may lead to severe mistreatment.
The oral cavity may exhibit a myriad of expansive lesions, including cysts, reactive lesions, and benign and malignant neoplasms. Additional laboratory examinations are therefore often used to specify the diagnosis. However, the clinical impact of errors committed in the laboratory is poorly described [1, 2]. Recent data suggest that errors in cancer diagnosis may occur in more than 10% of reviewed specimens . We report a case illustrating that modern diagnostic tools in some cases may confuse and mislead, rather than clarify a certain condition.
A few days after delivery, just before surgery was to be executed, the palatinal tumour spontaneously regrediated, and disappeared totally within weeks. Her teeth also fastened. The histopathologic diagnosis, unrelated to the clinical development, had at this point been revised to a possible hemangiopericytoma or a hemangiopericytoma-like lesion.
Two years later, the patient again became pregnant (extrauterine), and after about a month, a new tumour, similar to the previous and at the very same position, occurred. This also disappeared spontaneously after abortion.
Pyogenic granuloma is considered a reactive lesion, quite common in the oral cavity. It may clinically mimic several other lesions, including malignancies. The so-called pregnancy tumour is a pyogenic granuloma that seems to appear more easily in the gingiva during pregnancy due to hormonal influence. It can be fast-growing and reach a considerable size. After delivery or termination of pregnancy, they most often disappear spontaneously. The histopathology shows proliferating endothelial cells, the stroma is fibrillar, often arranged in lobular aggregates . The actual sections showed collagenous connective tissue with several blood vessels and a cell-rich area with diffuse cell borders and several mitotic cells. Despite the well-known clinical development of the lesion among the involved pathologists, later re-examinations have not been conclusive concerning histologic diagnosis, and the histopathological appearance seems not typical for any of the previously described entities. Nor is the CT scan typical for a pyogenic granuloma. Recent advances have identified antigens that may help distinguish vasoproliferative tumours [3, 5, 6], and it is likely that in the future, molecular techniques may play an even more important role in tumour diagnostics and also subsequent choice of treatment . Medical professionals, pathologists included, will probably still commit mistakes, particularly when deprived of or misleaded by e.g. insufficient clinical data . To detect and avoid such errors, different audit regimes have been proposed . In this particular case, most of the recommended audit strategies  were performed. Sarcomas and other relatively rare malignancies are at the Dept. of pathology dealt with by a dedicated group of pathologists, and foreign experts are consulted in special cases, including this one. There are also regular organised discussion meetings between pathologists and surgeons for all malignant tumours to avoid mistakes based on misinterpretation of clinical versus histological data.
The clinical course in this case is highly consistent with a pregnancy tumour. It is, to our best knowledge, not been reported that neither angiosarcomas nor hemangiopericytomas may undergo spontaneous regression. However, the possibility for hormonal and endothelial growth factor influence in vascular tumours during pregnancy is discussed [10, 11].
The patient has to this day not experienced any later recurrences of the lesion. Her two twin boys delivered as preparation for tumour treatment have also grown up perfectly healthy.
As medicine in general becomes increasingly dependent of laboratory investigations, sample analyses, and advanced imaging techniques, it is of great importance to emphasise the value of the clinical consultation as well. The case also reminds us that simple conditions may be misinterpreted, possibly causing serious mistreatment.
Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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