Appendectomy during the third trimester of pregnancy in a 27-year old patient: case report of a "near miss" complication
© Holzer et al; licensee BioMed Central Ltd. 2011
Received: 17 February 2011
Accepted: 17 May 2011
Published: 17 May 2011
The management of acute appendicitis during pregnancy is not fully established, especially regarding the choice between open and laparoscopic surgery during the third trimester. We report herein the case of a major uterine variecele hemorrhage during a laparoscopic appendectomy in a 27-year old pregnant patient at 33 weeks of amenorrhea. After conversion to a Pfannenstiel incision, the baby was delivered, the bleeding stopped and the appendectomy completed. While both mother and child fully recovered, this «near miss» complication underlines the challenges linked to the management of acute appendicitis during pregnancy. Based on a literature review, we propose an algorithm favoring the laparoscopic approach during the first and second trimesters, and the open approach during the third trimester (especially after the 26th week of amenorrhea). In case of unclear pre-operative diagnosis, a laparoscopy should be conducted even during the third trimester with a Mc Burney conversion when the diagnosis of appendicitis is confirmed.
Appendicitis is the most common cause of non-obstetrical operation. Its incidence is approximately one per 1500 patients, which is similar to the one in the non-pregnant population.
The diagnosis of acute appendicitis is more challenging during pregnancy . Up to 23% of appendectomies performed during pregnancy show normal appendices (versus 18% in non-pregnant patients, p < 0.05) . This observation is mainly related to underlying physiological and anatomical changes leading to atypical pain, both in intensity and location [3–6]. In addition, a physiological leucocytosis is present during pregnancy and urine analysis often shows the presence of red blood cells or positive cultures, which can be misleading .
Multiple investigations and/or false diagnoses can delay surgery and increase the risk of appendix perforation, which is associated with higher rates of maternal morbidity (52% versus 17% non-perforated appendicitis) and foetal mortality (24% versus 7%) . Conversely, performing an appendectomy for a false diagnosis of appendicitis is associated to at least similar rates of foetal loss and preterm delivery than regular appendectomies. Such complications may be related to the surgery itself and/or to the misdiagnosed disease [2, 7, 8].
Once the decision to operate has been made, the operative technique, open or laparoscopic surgery, must be decided. The laparoscopy is most often recommended during the first two trimesters, as alternative diagnoses can be evaluated in case of normal appendix [9–14]. During the third trimester, guidelines are less clear. Many speak for the open approach, especially after the 26th-28th week of amenorrhea, but an increasing number of publications now report series of successful laparoscopic appendectomies during the third trimester [7, 9, 10, 12–14].
The present case illustrates the risks and limitations of the laparoscopic approach during the third trimester of pregnancy and an algorithm based on the current literature is proposed for the management of appendicitis during pregnancy.
A healthy 27-year-old pregnant woman presented to our emergency department at 33 weeks of amenorrhea with worsening abdominal pain. She demonstrated right iliac fossa tenderness. Blood tests showed transient leucocytosis at 11.5 g/l (norm: 4-11 g/l) and C - reactive protein of 68 mg/l (norm: 0-20 mg/l). The abdominal ultrasonography demonstrated a thin appendix with neighbouring infiltration and free fluid, compatible with appendicitis.
While the patient was on the list for an emergency appendectomy, she described a migration of the pain to the left iliac fossa, with a complete disappearance of the right sided symptoms. The on-call gynaecologist was consulted and premature labour was suspected. The patient was transferred to the obstetrical ward for tocolysis and assessment under epidural anaesthesia. With the exclusion of a spontaneous labour, the absence of sign of chorioamnionitis and the observation of a healthy foetus, the abdominal pain remained unexplained. After discussion with the gynaecologist, a laparoscopic exploration was undertaken with the aims to obtain a final diagnosis and to perform an appendectomy (if appropriate).
After the introduction of a 12 mm supra-umbilical trocar, advanced phlegmonous appendicitis with turbid free fluid was found. A 5 mm trocar was inserted in the right hypochondrium and a 12 mm trocar in the right flank. The working space was very narrow because of the gravid uterus and the dissection of the appendix was difficult due to multiple adhesions between the uterus, the bladder and the caecum.
Evolution of hemoglobin, hematocrit, thrombocytes and coagulation with time.
23:45 (J0 postOP)
03:30 (J1 postOP)
12:00 (J1 postOP)
06:00 (J2 postOP)
Prothrombin time (%)
International normalised ratio
Partial thromboplastin time (sec)
While some studies have demonstrated that the laparoscopic approach is feasible until 32-34 weeks of amenorrhea, conversion rates are higher and operative times longer [9, 12–14]. This approach should, therefore, not be favoured during the third trimester. This said, we would still perform a laparoscopy during the third trimester in case of unclear pre-operative diagnosis. Once the intra-operative diagnosis of appendicitis has been made, we would favour a Mc Burney conversion (laparoscopy will guide the location of the open incision). We acknowledge however the difficulty of this decision, balancing a well progressing laparoscopic appendectomy, the potential complications to come and the safer profile of the open procedure.
Several key points may be helpful when the laparoscopic approach is chosen during pregnancy (whatever the trimester). They are based on the guidelines of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES): 
An obstetrical consultation with foetal heart monitoring is recommended pre- and post-operatively.
The patient should be positioned in the left lateral decubitus position to minimize the compression of the vena cava by the gravid uterus.
CO2 pressure should not be used higher than 10-15 mmHg. Ideally, the CO2 pressure should be lower than 12 mmHg in order to minimize foetal acidosis and improve maternal ventilation. This should however be achieved with an appropriate working space.
Maternal CO2 should be monitored by capnography.
Trocar placement should be planned according to the location of the gravid uterus.
Intra- and postoperative leg compression devices should be used to minimize the risk of thrombo-embolic events.
There is no data regarding the use of unfractionated or low-molecular weight heparin during pregnancy but heparin has proven to be safe for prophylactic use.
Tocolysis should not be used prophylactically but only in the presence of signs of preterm labor.
In case of major bleeding, an aggressive management should be performed, similar to those used in case of major bleeding after trauma .
While more difficult in a pregnant woman, the diagnosis of acute appendicitis should be as prompt as possible in order to minimize maternal morbidity and foetal mortality. When the diagnosis is not clear, we recommend performing a laparoscopic exploration. During the third trimester we recommend a conversion to an open appendectomy once the intra-operative diagnosis of appendicitis has been made.
Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Christian Toso was supported by the Swiss National Science Foundation (SCORE grant 3232230-126233).
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