Diagnosis of immune-mediated coagulopathy (IMC). In response to elevated PT/aPTT, IMC should be considered in the differential diagnosis for post-operative coagulopathy. Assays to rule out common causes of coagulopathies and mixing studies should be conducted. If the mixing study fails to correct, an inhibitor should be suspected. A hematology consult should be requested and factor assays conducted to confirm the diagnosis. (PT = prothrombin time; PTT = activated partial thromboplastin time; FFP = fresh frozen plasma).