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Feature: The Safety of Covid-19 mRNA Vaccines: A Review

The emergency use authorization for two novel mRNA vaccines against SARS-CoV-2 (Pfizer/BioNtech and Moderna) has ignited new hope towards bringing the COVID-19 pandemic to an end. While vaccine availability and vaccine delivery continue to impose significant challenges on a global scale, growing reports of individual vaccine hesitancy further impact the success of the vaccination campaign and the timeliness of achieving herd immunity against SARS-CoV-2. 

The current featured article provides an encompassing review on the safety of COVID-19 mRNA vaccines, with a focus on reported adverse events and side-effects from the Pfizer/BioNtech and Moderna vaccines. The low risk of severe adverse events after vaccination must be weighed against the benefits of containing the COVID-19 pandemic and thereby attenuating the global suffering from its devastating consequences.

About the Editor

"This is an exciting time to be involved in promoting a global culture of patient safety among all healthcare providers, particularly for the next generation of physicians and surgeons. Current patient safety protocols continue to fall short of protecting our patients from suffering unintended harm. Our journal provides a forum for reporting, discussing, and designing new patient safety standards for the future."

– Philip F. Stahel, Editor-in-Chief

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Editors-in-Chief
Prof Philip F Stahel, The Medical Center of Aurora, USA
Prof Pierre-Alain Clavien, University Hospital Zurich, Switzerland

Managing Editors
Prof Sebastian Weckbach, University Hospital Ulm, Germany
Dr Navid Ziran, St. Joseph's Hospital and Medical Center, Arizona, USA

Senior Editor Emeritus
Dr Steven Schelkun,  AO North America, USA
Prof George Youngson, Royal College of Surgeons of Edinburgh, Scotland

Associate Editors
Dr Darryl Auston, North Suburban Medical Center, Colorado, USA
Prof Walter Biffl, Scripps Memorial Hospital, USA
Prof Markus W Buechler, University Hospital Heidelberg, Germany
Dr. Jeffrey Galinkin, The Medical Center of Aurora, USA
Prof Christoph E Heyde, University Hospital Leipzig, Germany
Dr Michael Janssen, Center for Spinal Disorders, USA
Prof James Kellam, Carolinas Medical Center, USA
Dr Fernando Kim, Denver Health Medical Center, USA 
Prof Martin A Makary, The Johns Hopkins Hospital, USA 
Dr Claudia Medina, IPS Universitaria Clinica Leon XIII, Colombia
Prof Philip S Mehler, Eating Recovery Center, USA
Prof Ernest E Moore, Denver Health Medical Center, USA
Prof Hans-Christoph Pape, University Hospital Zurich, Switzerland
Prof Rodrigo Pesántez, Universidad de los Andes Bogotá, Colombia
Dr. Carlos Rodriguez, Walter Reed National Military Medical Center, USA
Prof Andrew H Schmidt, Minnesota University, USA
Dr Jeffrey Smith, Orthopaedic Trauma & Fracture Specialist Medical Corp, USA
Prof Wade R Smith, Swedish Medical Center, USA
Prof Adam Starr, University of Texas Southwestern Medical School, USA
Prof Charles Vincent, University of Oxford, UK
Dr Boris A. Zelle, University of Texas Health, USA
Prof Bruce Ziran, Hughston Clinic at Gwinnett Medical Center, USA

Statistical Advisors
Dr Stefan Sauerland, Institute for Quality and Efficiency in Healthcare (IQWiG), Germany
Dr Allison E Williams, Bay Pines VA Health Care System, USA

Editorial Board
Prof Fernando Baldy dos Reis, UNIFESP-Federal University of São Paulo, Brazil
Prof Jeffrey Barkun, McGill University Health Center, Canada
Dr Nathan C Butler, West Virginia School of Osteopathic Medicine, USA
Dr. Bayley E. Clarke, Georgetown University, USA
Dr Ted Clarke, Colorado Physician Insurance Companies (COPIC), USA
Prof Nicolas Demartines, University Hospital Lausanne (CHUV), Switzerland
Dr Johannes Fakler, University of Leipzig, Germany
Prof Joan Figueras, University Hospital Girona, Spain
Prof Beat Gloor, University of Bern, Switzerland
Dr Andrew Grose, Westchester Medical Center, USA 
Prof Dieter Hahnloser, University Hospital Lausanne (CHUV), Switzerland
Prof Jiandong Hao, The Third Hospital of Hebei Medical University, China
Prof Kirk Hogan, University of Wisconsin, USA
Prof Markus Huber-Lang, University of Ulm, Germany
Dr Kyros Ipaktchi, Denver Health Medical Center, USA
Dr Thilo John, DRK Hospital Berlin-Westend, Germany 
Dr Jeffrey L Johnson, Henry Ford Hospital, USA
Prof Jeffry Kashuk, Tel Aviv University-Sackler School of Medicine, Israel
Prof Christian K Lackner, LMU University, Germany
Dr Geeta Lal, University of Iowa, USA
Dr Alan Lembitz, Colorado Physician Insurance Companies (COPIC), USA
Prof Matthias Majetschak, Loyola University, USA
Dr Lucas McCormack, Hospital Aleman, Argentina
Dr Timothy Moore, MetroHealth Medical Center, USA
Dr John Mukhopadhaya, Mukhopadhaya Orthopaedic Clinic, India
Prof Giuseppe Nigri, Sapienza University of Rome, Italy
Dr Lena Nilsson, Linköping University Hospital, Sweden
Dr Robert Padbury, Flinders Medical Centre, Australia
Dr Fredric Pieracci, Denver Health Medical Center, USA
Prof John V Reynolds, Trinity College Dublin, Ireland 
Prof Taylor S Riall, University of Arizona, USA
Dr Andrew Robson, University of Edinburgh, UK
Prof Steven M. Strasberg, Washington University School of Medicine, USA
Dr Todd Swenning, Desert Regional Medical Center, USA
Dr Jeffrey Varnell, Colorado Physician Insurance Companies (COPIC), USA
Dr Ryan Will, Olympia Orthopaedic Association, USA
Dr Gerald Zarlengo, Colorado Physician Insurance Companies, USA