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Table 7 Supplemental oxygen delivery modalities, stratified by medications. Abbreviations: BiPAP, bilevel positive airway pressure; CPAP, continuous positive airway pressure; ECMO, extracorporeal membrane oxygenation

From: Investigational medications in 9,638 hospitalized patients with severe COVID-19: lessons from the “fail-and-learn” strategy during the first two waves of the pandemic in 2020

 

Azithro-mycin

Cortico-steroids

Hydroxy-chloroquine

Remdesivir

Tocilizumab

 
 

Early (N = 2539)

Late (N = 5341)

Early (N = 2711)

Late (N = 11,050)

Early (N = 1436)

Late (N = 143)

Early (N = 1013)

Late (N = 5852)

Early (N = 650)

Late (N = 451)

Total (N = 9,638)

Non-Invasive Ventilation Measures

2,303 (90.71%)

4,917 (92.06%)

2,516 (92.81%)

10,232 (92.60%)

1,299 (90.46%)

137 (95.80%)

972 (95.95%)

5,601 (95.71%)

614 (94.46%)

433 (96.01%)

8,709 (90.36%)

Nasal Oxygen Cannula

2,200 (86.65%)

4,709 (88.17%)

2,416 (89.12%)

9,805 (88.73%)

1,241 (86.42%)

135 (94.41%)

945 (93.29%)

5,401 (92.29%)

586 (90.15%)

401 (88.91%)

8,375 (86.90%)

Oxygen Mask

1,290 (50.81%)

2,635 (49.34%)

1,602 (59.09%)

5,917 (53.55%)

809 (56.34%)

72 (50.35%)

651 (64.26%)

3,370 (57.59%)

446 (68.62%)

305 (67.63%)

4,935 (51.20%)

BiPAP

583 (22.96%)

2,485 (46.53%)

880 (32.46%)

5,245 (47.47%)

244 (16.99%)

72 (50.35%)

372 (36.72%)

3,070 (52.46%)

249 (38.31%)

283 (62.75%)

2,955 (30.66%)

CPAP

171 (6.73%)

622 (11.65%)

272 (10.03%)

1,491 (13.49%)

86 (5.99%)

18 (12.59%)

119 (11.75%)

833 (14.23%)

71 (10.92%)

65 (14.41%)

872 (9.05%)

Invasive Ventilation

1,233 (48.56%)

2,509 (46.98%)

1,515 (55.88%)

5,699 (51.57%)

871 (60.65%)

89 (62.24%)

536 (52.91%)

3,026 (51.71%)

444 (68.31%)

316 (70.07%)

4,833 (50.15%)

Tracheo-stomy

66 (2.60%)

176 (3.30%)

97 (3.58%)

394 (3.57%)

40 (2.79%)

10 (6.99%)

44 (4.34%)

212 (3.62%)

22 (3.38%)

21 (4.66%)

303 (3.14%)

ECMO

14 (0.55%)

28 (0.52%)

33 (1.22%)

101 (0.91%)

15 (1.04%)

0 (0.00%)

23 (2.27%)

48 (0.82%)

10 (1.54%)

7 (1.55%)

106 (1.10%)

  1. Declarations